Moralo o mocha oa thepa e tala

Boiketsi ba limolek'hule

--a frontier green chemistry without bond breaking and reconnection

Molao-motheo oa ho ikopanya ha molek'hule:

1. Joaloka ho hohela joaloka - ho khanna lintho tse tšoanang ho bokella le ho hlophisa tse ling, le lintho tse nang le thepa e tlatsetsang ho hohelana.

2. Matla a tlaase ka ho fetisisa-ho sisinyeha ha lintho le boitšoaro ba limolek'hule li tla sekamela boemong bo tsitsitseng ka ho fetisisa. Ke mokhoa oa hore lihlopha tsa limolek'hule li hlophisoe ka mekhoa e tsoetseng pele.

Boikoetliso ba limolek'hule, sebopeho sa CP lipakeng tsa limolek'hule se ka ntlafatsa haholo ts'ebetso ea tlhaho:

1. Molek'hule e 'ngoe le e' ngoe e na le sebopeho sa eona se ikhethang le lisebelisoa tse sebetsang, 'me ho thata ho finyella synergy le phekolo e nepahetseng e thehiloeng ho kopanya mahala boemong ba ho hlophisoa.

2. Ho ntse ho e-na le limolek'hule tse ngata tse nang le ts'ebetso e babatsehang ea likokoana-hloko tse fokolitseng haholo ho monya le ho sebelisoa ha tsona ka lebaka la litšobotsi tsa tsona tse mpe.

3. Lintho tse sebetsang tsa meriana ea setso ea Sechaena li khethehile haholo ka "morena, basebeletsi le bathusi", ho e-na le ho ba le li-hodgepodge tse molemo haholoanyane.

Phetoho ea sebopeho sa Supramolecular le mokhoa oa ts'ebetso ea ho ntlafatsa:

1. Tlhahlobo ea lisebelisoa tse phahameng tsa k'homphieutha bakeng sa ho hlahloba ka potlako li-precursors tse loketseng ho tloha Cambridge Crystal Data Center.

2. Sebelisa khopolo ea ts'ebetso ea density ho ithuta sebopeho sa supramolecular le thepa ea kopano e khethiloeng ke matla a intermolecular, le ho fumana hore na ke mofuta ofe oa supramolecular o leng mokhoa oa ho thehoa.

3. Ka ho hlahloba maemo a karabelo le bothata, sebopeho sa supramolecular se ile sa ntlafatsoa.

4. Palo ea thepa e sa tšoaneng ea li-supramolecules, ho kenyelletsa le thepa ea motlakase, ea optical le thermodynamic.

5. Palo ea thepa ea spectral e kang spectrum ea molek'hule le matla a matla.

6.Ka theknoloji ea ho etsa limolek'hule, libaka tsa tšebelisano pakeng tsa lisebelisoa tse tala tsa supramolecular le liprotheine tse lebisitsoeng li boleloa esale pele, 'me mokhoa oa ho sebelisana pakeng tsa limolek'hule o hlalosoa ka botebo.

Theknoloji ea letsoai ea Supramolecular eutectic / Ionic letsoai

Likarolo tsa tekheniki: indasteri ea pele, e lekola likarolo tse ntle ka ho fetisisa tsa CP tsa likarolo tse sebetsang bakeng sa ho matlafatsa eutectic

Melemo: fokotsa ho teneha, ntlafatsa solubility, ntlafatsa tshebetso, khothalletsa permeability, ntlafatsa botsitso

Mehlala ea metsoako: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK.

Lisebelisoa tsa tlhaho tse sebetsang tse nkiloeng lethathamong la lisebelisoa tse tala tsa litlolo, kamora liteko tsa netefatso tse kang quantum chemical simulation, high-throughput screening, Gaussian optimization, KingDraw, MestReNova, FTIR, le NMR, lihlahisoa tse fumanoeng li na le sebopeho se setle sa kristale ea likarolo tse tharo, botsitso bo botle, bohloeki bo phahameng, litšila tse fokolang. E ka rarolla ka katleho lintlha tsa bohloko ba kopo ea lisebelisoa tse sebetsang lijong, meriana le litlolo, le ho ntlafatsa bioavailability le polokeho ea metsoako e sebetsang.

Theknoloji ea tlhahiso ea mesebetsi ea supramolecular

likarolo tsa echnical: Ea pele ea indasteri, motsoako oa theknoloji ea khatiso ea limolek'hule le li-solvents tsa tlhaho tsa supramolecular, tlhahiso e sebetsang ea metsoako e sebetsang ea semela.

Melemo: Ho ntšoa ho lebeletsoeng, bokhoni ba ho ntša metsi bo eketseha ka makhetlo a 5 ha ho bapisoa le ho ntšoa ha joala, 'me ho ntšoa ha metsi ho eketseha ka makhetlo a 20; ha ho na karohano, ho fokotsa litšenyehelo, metsoako e khothalletsang ho kenella Mehlala: mohloaare (oleuropein, hydroxytyrosol), rhodiola, Phyloporus ea meriana, khahla ea metsi a tšoeu, micrococcus.

Natural deep eutectic solvent (NaDES): E ile ea qala ho sibolloa ke bo-rasaense ha ho hlahlojoa metabolomics ea limela. Nakong ea mehato e itseng ea tsoelo-pele ea limela (ho mela, cryopreservation), lisele li tla iketsetsa mokelikeli o khanyang haholo o ikemetseng ntle le metsi le lipids, o tšoanang le motsoako oa eutectics.

Ho ipapisitsoe le theknoloji ea sejoale-joale ea karohano ea botala, theknoloji e kopaneng ea membrane, e tlatsitsoeng ke theknoloji ea ntlafatso ea ultrasonic / microwave ho fihlela mocheso o tlase, sepheo, ciency e phahameng, boleng bo holimo le botala bo botala ba likarolo tse sebetsang. Supramolecular solvent e khethiloeng e na le ts'ebetso e tsitsitseng le ho qhibiliha ho matla ha metsoako e sebetsang, le katleho ea ho ntša e ka eketsoa ka makhetlo a 20.

Theknoloji ea ho kenella ea supramolecular synergistic

Likarolo tsa tekheniki: Ea pele ea indasteri, ka supramolecular solvent synergistically e khothaletsa ho kenella ha macromolecules / ho qhibiliha ha metsi / ho thata ho monya metsoako.

Melemo ea tekheniki: botsitso bo ntlafetseng, ntlafatso e sa senyeheng le e sebetsang hantle ea ho kenella, phello ea synergistic, ntlafatso ea tataiso ho dermis, le bioavailability e eketsehile ka makhetlo a 5-7 Mehlala ea metsoako: collagen, Bosein, peptide ea koporo e putsoa, ​​hexapeptide, peptide e kopantsoeng, β-glucan.

Kaha boima ba limolek'hule tsa peptide bo ntse bo le boholo ha bo bapisoa le lisebelisoa tse ling tse sebetsang, ho kenella ha letlalo ho batla ho le tlaase. Ho hlokahala mekhoa e meng e matlafatsang ho kenella ho ntlafatsa matla a ho monya a peptide, e le ho fihlela mahloriso a tlase le katleho e phahameng, le ho fihlela katleho e ntle ea ho thibela botsofali.

E le karabelo ho indasteri e bohloko ea ho kenella ka thata, hydrophilicity e phahameng le bioavailability e tlase ea li-macromolecules tsa setso, JUNAS Time Particle products synthesis ka quantum chemistry e thusitse, e ka fihla ka kotloloho ho epidermis le dermis ea letlalo ka li-trans-cellular, intercellular le follicular sweat ductchannels. Ntle le ho senya sebopeho sa letlalo.The bioavailability ea sehlahisoa e eketseha ka makhetlo a 5, ho kenyelletsa le ho feta 45% ho dermis, ntle le ho senya sebopeho sa letlalo.Phello ea ho kenella le nako ea ho lula e fihletsoe ntlafatso ea bohlokoahali.Ena ke ea pele ea mofuta oa eona indastering.

Theknoloji ea supramolecular biocatalysis

Catalysis e tsamaisitsoeng ke bioenzyme: li-solvents tsa supramolecular li sebelisoa e le li-substrates ho ntlafatsa ts'ebetso ea enzyme, ho ntlafatsa khetho ea li-chiral, le ho fihlela bohloeki bo phahameng.

Boenjiniere ba fennel botala bo botala: khetha limela tse ikhethang, ntlafatsa litaba tsa metsoako e sebetsang, foromo ea anhydrous, ntlafatsa katleho ka kakaretso.

Theknoloji e khutlisetsang morao ea micellar fermentation: ho lekola mefuta e meng, ho belisa oli ea meroho, litlamorao tse ngata, ho ntlafatsa maikutlo a letlalo le ho monyeha.

Ho ipapisitsoe le thekenoloji ea liphatsa tsa lefutso, mokhoa o le mong oa theknoloji ea ho kopanya liphatsa tsa lefutso le tekhenoloji e matla ea bioenzyme catalytic, libaktheria tse entsoeng ka liphatsa tsa lefutso li sebelisoa e le bajari ba matla ho hlokomela tlhahiso e kholo ea lintho tse sebetsang:

Tlas'a sisteme ea supramolecular solvent, enzyme e bonts'a ts'ebetso e phahameng, khetho le botsitso, ts'ebeliso e phahameng ea lisebelisoa tse tala tsa substrate, tšilafalo e nyane ts'ebetsong ea tlhahiso, maemo a karabelo e bonolo, ts'ebetso e phahameng ea ts'ireletso le ts'ebetso ea tlhahiso.

Theknoloji ea morao-rao ea ho belisoa ha micelle:

oli e khethiloeng ea tlhaho e nang le litšobotsi tsa Sechaena lP e entsoe ka boithaopo ho hlahisa li-surfactants tlas'a ts'ebetso ea libaktheria tse entsoeng ka liphatsa tsa lefutso.lt e bokelloa e le mojari oa li-anti-micellar bundle ho hlokomela ho phuthela ha li-anti-micellar bundle tsa metsoako e sebetsang e qhibilihang ka metsing ho finyella maemo a mangata a ts'ebeliso, phihlelo ea ho qetela ea letlalo, le phihlelo e tsotehang, katleho le bohlokoa.

Theknoloji ea Supramolecular microencapsulation

Likarolo tsa tekheniki: liposome encapsulation, tokollo e lebisitsoeng ea lisele tsa dermal, tokollo e lebisitsoeng ea li-follicle tsa moriri, le tokollo e arabelang ea mabaka a ho ruruha.

Melemo: Nanoization, phano e nepahetseng, tokollo e tšoarellang nako e telele, ho fokotsa ho teneha, ho ntlafatsa botsitso, le ho khothaletsa ho kenella.

Mehlala ea metsoako: astaxanthin, glabridin, vithamine A, peptide ea koporo e putsoa, ​​biotin, ceramide, oli ea bohlokoa ea semela.

Theknoloji ea Supramolecular microencapsulation e thehiloe holim'a liposome, emulsion ea mafura, theknoloji ea ionic liquid stabilization, dermal cell targeted release technology, follicle ea moriri e lebisitsoeng ho lokolla theknoloji, le theknoloji ea ho lokolla e arabelang ka lebaka la ho ruruha. E na le sekhahla se setle sa ho monya ha transdermal, nako ea ho lula nako e telele le botsitso bo botle sebakeng se shebiloeng letlalong. E boetse e na le lits'ebetso tse theko e tlase le tse sebetsang hantle lefapheng la litlolo, lijo tse sebetsang le meriana.

Peptide hierarchical self-assembling theknoloji

Likarolo tsa tekheniki: taolo ea indasteri ea pele, e lebisitsoeng ho sebopeho sa mekhahlelo e mengata ea liketane tsa amino acid le polypeptides, li-peptide tse khutšoane tse ipokelletseng, li-polypeptides tsa supramolecular.

Tataiso ea tekheniki: Ntlafatsa amphiphilicity, ntlafatsa botsitso le ho hanyetsa mocheso, fokotsa chefo le khatello ea 'mele ea ho itšireletsa mafung, ho khothaletsa ho monya, le ho kopanya.

Mehlala ea metsoako: supramolecular carnosine, yeast protein peptide

Ho ipokella ha liprotheine le li-peptide ha ho hohle feela lits'ebetsong tsa bophelo, empa hape ke ntho e ntle ea 'mele oa motho, hape ke e' ngoe ea mekhoa e sebetsang ea ho kopanya lisebelisoa tsa nano-biological. Ts'ebetso ea ho ipokella ha li-peptide ke ts'ebetso ea ho bokana ka maemo a holimo, 'me "polar amino acid zipper structure" ke mofuta o mocha oa sebopeho sa maemo a holimo-limo, o loketseng kopano ea maemo a holimo ea li-peptide ho theha lihlopha tse hlophisitsoeng.

Taolo ea tataiso ea boholo ba li-peptide tse khutšoane e ka finyelloa ka ho fetola hydrophobicity le lehlakore la ketane ea masala a hydrophobic.

Thehiloeng ho Shinehigh Innovation's ikhethang ProteinDataBank (PDB) polokelongtshedimosetso, kopana le thulaganyo ya tekolo bobservation, dynamics molek'hule le quantum k'hemistri dipalelo ho sekaseka sebopeho sa limolek'hule peptide, 'me joale li bapisa le limolek'hule tsa ho ikamahanya le maemo a phahameng. ka hona ho ntlafatsa bokgoni ba molek'hule ho ikgobokanya.Lemoha molao o lebisitsweng wa di-peptide. Peptide e ikemetseng e na le amphiphilicity le symmetry e babatsehang, e ntlafatsang haholo botsitso ba peptide, bokhoni ba transdermal le bioavailability.